PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
Identifieur interne : 001638 ( Main/Exploration ); précédent : 001637; suivant : 001639PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
Auteurs : Joana Matos [Portugal] ; Nuno Vale [Portugal] ; Margaret S. Collins [États-Unis] ; Jiri Gut [États-Unis] ; Philip J. Rosenthal [États-Unis] ; Melanie T. Cushion [États-Unis] ; Rui Moreira [Portugal] ; Paula Gomes [Portugal]Source :
- MedChemComm [ 2040-2503 ] ; 2010.
English descriptors
- Teeft :
Abstract
Primacenes, novel ferroceneprimaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active against Pneumocystis carinii and devoid of cytotoxicity, thus being more selective than the parent drug.
Url:
DOI: 10.1039/c0md00082e
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002940
- to stream Istex, to step Curation: 002940
- to stream Istex, to step Checkpoint: 000583
- to stream Main, to step Merge: 001641
- to stream Main, to step Curation: 001638
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity</title><author wicri:is="90%"><name sortKey="Matos, Joana" sort="Matos, Joana" uniqKey="Matos J" first="Joana" last="Matos">Joana Matos</name></author><author wicri:is="90%"><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name></author><author wicri:is="90%"><name sortKey="Collins, Margaret S" sort="Collins, Margaret S" uniqKey="Collins M" first="Margaret S." last="Collins">Margaret S. Collins</name></author><author wicri:is="90%"><name sortKey="Gut, Jiri" sort="Gut, Jiri" uniqKey="Gut J" first="Jiri" last="Gut">Jiri Gut</name></author><author wicri:is="90%"><name sortKey="Rosenthal, Philip J" sort="Rosenthal, Philip J" uniqKey="Rosenthal P" first="Philip J." last="Rosenthal">Philip J. Rosenthal</name></author><author wicri:is="90%"><name sortKey="Cushion, Melanie T" sort="Cushion, Melanie T" uniqKey="Cushion M" first="Melanie T." last="Cushion">Melanie T. Cushion</name></author><author wicri:is="90%"><name sortKey="Moreira, Rui" sort="Moreira, Rui" uniqKey="Moreira R" first="Rui" last="Moreira">Rui Moreira</name></author><author wicri:is="90%"><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:774B7597D3CEB6C72515DF622204D302B91A3299</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1039/c0md00082e</idno><idno type="url">https://api.istex.fr/ark:/67375/QHD-F651NJVS-W/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002940</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002940</idno><idno type="wicri:Area/Istex/Curation">002940</idno><idno type="wicri:Area/Istex/Checkpoint">000583</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000583</idno><idno type="wicri:doubleKey">2040-2503:2010:Matos J:primacenes:novel:non</idno><idno type="wicri:Area/Main/Merge">001641</idno><idno type="wicri:Area/Main/Curation">001638</idno><idno type="wicri:Area/Main/Exploration">001638</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity</title><author wicri:is="90%"><name sortKey="Matos, Joana" sort="Matos, Joana" uniqKey="Matos J" first="Joana" last="Matos">Joana Matos</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Centro de Investigao em Qumica, Universidade do Porto, P-4169-007, R. do Campo Alegre, 687, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Departamento de Qumica e Bioqumica, Faculdade de Cincias, Universidade do Porto, P-4169-007, R. do Campo Alegre, 687, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Portugal</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Portugal</country></affiliation></author><author wicri:is="90%"><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Centro de Investigao em Qumica, Universidade do Porto, P-4169-007, R. do Campo Alegre, 687, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Departamento de Qumica e Bioqumica, Faculdade de Cincias, Universidade do Porto, P-4169-007, R. do Campo Alegre, 687, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Portugal</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Portugal</country></affiliation></author><author wicri:is="90%"><name sortKey="Collins, Margaret S" sort="Collins, Margaret S" uniqKey="Collins M" first="Margaret S." last="Collins">Margaret S. Collins</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Services, Veterans Affairs Medical Center, 45220, OH, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati, 45267-0560, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author wicri:is="90%"><name sortKey="Gut, Jiri" sort="Gut, Jiri" uniqKey="Gut J" first="Jiri" last="Gut">Jiri Gut</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, San Francisco General Hospital, University of California, 94143-0811, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author wicri:is="90%"><name sortKey="Rosenthal, Philip J" sort="Rosenthal, Philip J" uniqKey="Rosenthal P" first="Philip J." last="Rosenthal">Philip J. Rosenthal</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, San Francisco General Hospital, University of California, 94143-0811, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author wicri:is="90%"><name sortKey="Cushion, Melanie T" sort="Cushion, Melanie T" uniqKey="Cushion M" first="Melanie T." last="Cushion">Melanie T. Cushion</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Services, Veterans Affairs Medical Center, 45220, OH, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati, 45267-0560, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author wicri:is="90%"><name sortKey="Moreira, Rui" sort="Moreira, Rui" uniqKey="Moreira R" first="Rui" last="Moreira">Rui Moreira</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>iMed.UL, Faculdade de Farmcia, Universidade de Lisboa, P-1600-083, Av. Professor Gama Pinto, Lisboa</wicri:regionArea><wicri:noRegion>Lisboa</wicri:noRegion></affiliation></author><author wicri:is="90%"><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Centro de Investigao em Qumica, Universidade do Porto, P-4169-007, R. do Campo Alegre, 687, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Departamento de Qumica e Bioqumica, Faculdade de Cincias, Universidade do Porto, P-4169-007, R. do Campo Alegre, 687, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Portugal</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Portugal</country></affiliation></author></analytic><monogr></monogr><series><title level="j">MedChemComm</title><title level="j" type="abbrev">Med. Chem. Commun.</title><idno type="ISSN">2040-2503</idno><idno type="eISSN">2040-2511</idno><imprint><publisher>The Royal Society of Chemistry.</publisher><date type="published" when="2010">2010</date><biblScope unit="volume">1</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="199">199</biblScope><biblScope unit="page" to="201">201</biblScope></imprint><idno type="ISSN">2040-2503</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">2040-2503</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Agents chemother</term><term>Antimalarial</term><term>Biot</term><term>Carinii</term><term>Chem</term><term>Clogp values</term><term>Ferrocene core</term><term>Ferrocenecarboxylic acid</term><term>Gomes</term><term>Immunocompromised individuals</term><term>Moreira</term><term>Novel conjugates</term><term>Parent drug</term><term>Pneumocystis carinii</term><term>Primacenes</term><term>Royal society</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Primacenes, novel ferroceneprimaquine conjugates, were synthesized and screened for their antimalarial and anti-pneumocystis activity. Primacenes obtained by coupling primaquine amino acid derivatives to ferrocenoic acid were significantly active against Pneumocystis carinii and devoid of cytotoxicity, thus being more selective than the parent drug.</div></front></TEI><affiliations><list><country><li>Portugal</li><li>États-Unis</li></country><region><li>Californie</li><li>Ohio</li></region></list><tree><country name="Portugal"><noRegion><name sortKey="Matos, Joana" sort="Matos, Joana" uniqKey="Matos J" first="Joana" last="Matos">Joana Matos</name></noRegion><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><name sortKey="Matos, Joana" sort="Matos, Joana" uniqKey="Matos J" first="Joana" last="Matos">Joana Matos</name><name sortKey="Matos, Joana" sort="Matos, Joana" uniqKey="Matos J" first="Joana" last="Matos">Joana Matos</name><name sortKey="Matos, Joana" sort="Matos, Joana" uniqKey="Matos J" first="Joana" last="Matos">Joana Matos</name><name sortKey="Moreira, Rui" sort="Moreira, Rui" uniqKey="Moreira R" first="Rui" last="Moreira">Rui Moreira</name><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name></country><country name="États-Unis"><noRegion><name sortKey="Collins, Margaret S" sort="Collins, Margaret S" uniqKey="Collins M" first="Margaret S." last="Collins">Margaret S. Collins</name></noRegion><name sortKey="Collins, Margaret S" sort="Collins, Margaret S" uniqKey="Collins M" first="Margaret S." last="Collins">Margaret S. Collins</name><name sortKey="Cushion, Melanie T" sort="Cushion, Melanie T" uniqKey="Cushion M" first="Melanie T." last="Cushion">Melanie T. Cushion</name><name sortKey="Cushion, Melanie T" sort="Cushion, Melanie T" uniqKey="Cushion M" first="Melanie T." last="Cushion">Melanie T. Cushion</name><name sortKey="Gut, Jiri" sort="Gut, Jiri" uniqKey="Gut J" first="Jiri" last="Gut">Jiri Gut</name><name sortKey="Rosenthal, Philip J" sort="Rosenthal, Philip J" uniqKey="Rosenthal P" first="Philip J." last="Rosenthal">Philip J. Rosenthal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001638 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001638 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:774B7597D3CEB6C72515DF622204D302B91A3299
|texte= PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity
}}
| This area was generated with Dilib version V0.6.33. |  |